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Feature Article: Random Versus Targeted Biopsies for Colorectal Cancer Surveillance in Inflammatory Bowel Disease

Categories: Colon Cancer, IBD

July 2010 Volume 6, Issue 7

Tasneem Ahmed, DO, Jennifer Monti, MD, and Bret Lashner, MD

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For many years, cancer surveillance colonoscopy in ulcerative colitis patients has involved obtaining at least 30 biopsies of flat and abnormal-appearing mucosa. With the advent of better imaging techniques, biopsies can be better targeted to abnormal-appearing mucosa, thereby increasing the sensitivity of testing. Use of chromoendoscopy, narrow-band imaging, autofluorescence, or confocal endomicroscopy to target biopsies is likely to improve detection of dysplasia and identification of patients at high risk for developing cancer.

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